Driven by megatrends which include the pandemic, climate change, technological progress and social change, transformation in higher education is necessary in order to ensure that the system meets the needs of society and the economy, enabling Thailand to overcome global and local challenges. Contrary to the older concepts, higher education no longer caters exclusively to students prior to entering the job market, but also supports lifelong learning for people of all ages and occupations to increase the skill and competency level for social and economic development. Reskilling, upskilling and new skilling programs have never been more vital as the country needs to prepare skilled workers to build its new engines of growth as well as to attract investors of advanced industry to relocate to Thailand due to the shift in global economic power.